Pharmacological action Zyrtec Cetirizine 10 mg
Antiallergic drug. Blocker histamine H1-receptor Hydroxyzine metabolite. Prevents the development and facilitates the course of allergic reactions, has antipruritic and antiexudative action. Affect the early stage of allergic reactions gistaminozavisimuyu, limits the release of inflammatory mediators in the late phase allergic reactions, reduces the migration of eosinophils, neutrophils and basophils, stabilizing the membrane of mast cells.
Reduces the permeability of the capillaries, prevents the development of edema, relieves spasm of smooth muscles. Eliminates skin reaction to the introduction of histamine, specific allergens, as well as for cooling (when the “cold” hives). Reduces histamine-induced bronchoconstriction in asthma light flow. Practically no anticholinergic and antiserotoninovogo action. At therapeutic doses, has practically no sedation. Start effect after single dose of 10 mg cetirizine observed after 20 min (50% of patients) and 60 min (95% of patients), the effect lasts longer than 24 hours on the background of a course of treatment tolerance to antihistaminic effect of cetirizine does not develop. After cessation of treatment effect persists up to 3 days.
Pharmacokinetics Zyrtec Cetirizine 10 mg
Absorption
After ingestion is rapidly absorbed. Cmax is achieved through a 1 hour reception with food preparation does not affect the absorption, but the rate of absorption is somewhat reduced (time to Cmax increased by 1 h). Distribution of Cetirizine bound to plasma proteins at 93%. Vd – 0.5 L / kg. Excreted in breast milk. Not accumulates.
Metabolism
In small quantities, is metabolized in the liver by O-dezalkirovaniya to form a pharmacologically inactive metabolite (unlike other histamine H1-blocker receptors, metabolised in the liver involving the cytochrome P450).
Derivation of two thirds of the drug excreted unchanged in the urine and about 10% – in the feces. Systemic clearance – 53 ml / min. T1 / 2 7-10 pm practice is not removed by hemodialysis.
Pharmacokinetics in special clinical situations
T1 / 2 in children aged 6-12 years – 6 hours in children 2-6 years old – 5 hours in children aged 6 months to 2 years – 3.1 hours in elderly patients, the T1 / 2 increased by 50% , systemic clearance – 40%.
Statement Zyrtec Cetirizine 10 mg
The drug used in adults and children aged 6 months and older.
Treatment of symptoms:
year-round and seasonal allergic rhinitis and allergic conjunctivitis, such as itching, sneezing, rhinorrhea, lacrimation, conjunctival hyperemia;
hay fever (hay fever);
urticaria (including chronic idiopathic urticaria);
angioedema;
other allergic dermatitis (including atopic dermatitis), accompanied by itching and rashes.
Dosage regimen Zyrtec Cetirizine 10 mg
The drug is prescribed inside.
Children aged 6 months to 1 year to designate 2.5 mg (5 drops) one time / day.
Children aged 1 to 2 years is prescribed for the 2.5 mg (5 drops) 2 times / day.
Children aged 2 to 6 years prescribed by 2.5 mg (5 drops) 2 times / day or 5 mg (10 drops) 1 times / day.
Adults and children over 6 years prescribed in doses of 10 mg (1 tab. Or 20 drops) / day.
Adults – 10 mg 1 time / day for children – 5 mg 2 times / day or 10 mg 1 time / day. Sometimes an initial dose of 5 mg may be sufficient to achieve a therapeutic effect. In renal failure dose is reduced depending on the spacecraft.
Side effect Zyrtec Cetirizine 10 mg
CNS: drowsiness, headache, rare – dizziness, headache.
From the digestive system: dry mouth, rarely – diarrhea.
Allergic reactions: seldom – angioedema, pruritus, rash, urticaria.
Contraindications Zyrtec Cetirizine 10 mg
pregnancy;
Lactation (breastfeeding);
Children up to age 6 months;
hypersensitivity to the drug or to hydroxyzine.
Precautions should be prescribed the drug for chronic renal failure (moderate or severe degree), as well as elderly patients (due to a possible decrease in glomerular filtration rate).
Pregnancy and lactation Zyrtec Cetirizine 10 mg
The drug is contraindicated during pregnancy and lactation (breastfeeding).
Use in renal impairment
Precautions should be prescribed the drug for chronic renal failure (moderate or severe degree), as well as elderly patients (due to a possible decrease in glomerular filtration rate). In renal failure dose is reduced depending on the spacecraft.
Cautions Zyrtec Cetirizine 10 mg
No evidence of drug interaction Zirtek when applied at recommended doses of alcohol (at a concentration of blood ethanol 0.5 g / l), however it is recommended to refrain from drinking alcohol while taking Zirteka.
Effects on ability to drive and control mechanisms
Objective methods of studying the capacity for studies of potentially dangerous activities were not significantly reveal any adverse effects when using the drug at the recommended dose of 10 mg, however it is recommended to be cautious.
Overdose Zyrtec Cetirizine 10 mg
When receiving a single dose of the drug over 50 mg may experience the following symptoms: sleepiness, restlessness, irritability, urinary retention, dry mouth, constipation, mydriasis, tachycardia. Treatment: removal of the drug, gastric lavage, the appointment of activated charcoal, symptomatic therapy.
Drug Interactions Zyrtec Cetirizine 10 mg
In a joint appointment Zirteka with theophylline, 400 mg 1 time / day there was a reduction of spacecraft by 16%. In a joint appointment with macrolides and ketoconazole is not marked changes in the EKG. Clinically significant interactions with concomitant administration of drugs with pseudoephedrine, Zirtek, cimetidine, ketoconazole, erythromycin, azithromycin, diazepam, glipizide is not observed.
